Iron Metabolism in Rats with Phenylhydrazine-induced Hemolytic Disease.

By MARCEL E. CONRAD, LEWIS R. WEINTRAUB AND WILLIAM H. CROSBY T HE QUANTITY of iron present in the body is regulated by a balance between iron absorption and loss.15 Iron-deficient and iron-loaded animals and humans attempt to re-establish a normal body store of iron by regulating absorption16 and a limited but selective loss of body iron.58 The hemolytic states are unusual in that increased absorption continues in the face of an iron-replete body store without accumulating iron in massive quantities.8’#{176} The purpose of this study is to examine the mechanisms regulating iron absorption and loss in the hemolytic state produced by administration of acetylphenylhydrazine ( AcPh).